{"id":6197,"date":"2020-03-25T16:06:18","date_gmt":"2020-03-25T19:06:18","guid":{"rendered":"https:\/\/www.ufsm.br\/midias\/arco\/?p=6197"},"modified":"2020-04-08T10:32:20","modified_gmt":"2020-04-08T13:32:20","slug":"ibuprofeno-agrava-quadro-covid19","status":"publish","type":"post","link":"https:\/\/www.ufsm.br\/midias\/arco\/ibuprofeno-agrava-quadro-covid19","title":{"rendered":"Ibuprofeno agrava o quadro de covid-19?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"6197\" class=\"elementor elementor-6197\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bec2847 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bec2847\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9e85f4c\" data-id=\"9e85f4c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2f81501 elementor-widget elementor-widget-text-editor\" data-id=\"2f81501\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-size: 12pt;font-family: Arial;color: #222222;font-style: italic;vertical-align: baseline\">Os efeitos negativos do anti inflamat\u00f3rio em rela\u00e7\u00e3o ao novo coronav\u00edrus n\u00e3o est\u00e3o comprovados, mas pesquisas recentes levantam esse questionamento e formulam algumas hip\u00f3teses. Portanto, faltam evid\u00eancias.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9f41f05 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9f41f05\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-715afb8\" data-id=\"715afb8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-54f2023 elementor-widget elementor-widget-text-editor\" data-id=\"54f2023\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p dir=\"ltr\" style=\"line-height: 1.38;text-align: justify;margin-top: 0pt;margin-bottom: 0pt\"><span style=\"font-size: 12pt;font-family: Arial;color: #000000;background-color: #ffffff;font-weight: 400;font-style: normal;font-variant: normal;text-decoration: none;vertical-align: baseline\">O ministro da Sa\u00fade da Fran\u00e7a, Oliver V\u00e9ran, alertou, em seu <\/span><a style=\"text-decoration: none\" href=\"https:\/\/twitter.com\/olivierveran\/status\/1238776545398923264\"><span style=\"font-size: 12pt;font-family: Arial;color: #000000;background-color: #ffffff;font-weight: 400;font-style: normal;font-variant: normal;text-decoration: underline;vertical-align: baseline\">Twitter<\/span><\/a><span style=\"font-size: 12pt;font-family: Arial;color: #000000;background-color: #ffffff;font-weight: 400;font-style: normal;font-variant: normal;text-decoration: none;vertical-align: baseline\"> no dia 14 de mar\u00e7o, que medicamentos como ibuprofeno podem agravar a infec\u00e7\u00e3o do coronav\u00edrus. No dia 17 de mar\u00e7o, a <\/span><a style=\"text-decoration: none\" href=\"https:\/\/www.facebook.com\/WHO\/posts\/2993742374004459\"><span style=\"font-size: 12pt;font-family: Arial;color: #1155cc;background-color: #ffffff;font-weight: 400;font-style: normal;font-variant: normal;text-decoration: underline;vertical-align: baseline\">Organiza\u00e7\u00e3o Mundial da Sa\u00fade<\/span><\/a><span style=\"font-size: 12pt;font-family: Arial;color: #000000;background-color: #ffffff;font-weight: 400;font-style: normal;font-variant: normal;text-decoration: none;vertical-align: baseline\"> declarou que n\u00e3o \u00e9 recomendado utilizar o rem\u00e9dio como tratamento para Covid-19.<\/span><\/p><p><span id=\"docs-internal-guid-68455802-7fff-4a38-8630-cd37d003e59b\"><br \/><span style=\"font-size: 12pt;font-family: Arial;color: #000000;vertical-align: baseline\">De fato, a Revista Cient\u00edfica <\/span><a href=\"https:\/\/www.thelancet.com\/action\/showPdf?pii=S2213-2600%2820%2930116-8\"><span style=\"font-size: 12pt;font-family: Arial;color: #000000;vertical-align: baseline\">The Lancet <\/span><\/a><span style=\"font-size: 12pt;font-family: Arial;color: #000000;vertical-align: baseline\">publicou um artigo, no dia 11 de mar\u00e7o deste ano, sobre comorbidades e coronav\u00edrus. Ou seja, o texto trata da rela\u00e7\u00e3o entre doen\u00e7as cr\u00f4nicas preexistentes, como hipertens\u00e3o e diabetes, em pacientes que contra\u00edram Covid-19. A pesquisa ainda cita os poss\u00edveis efeitos prejudiciais do ibuprofeno.<\/span><\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-39555fa\" data-id=\"39555fa\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6584de1 elementor-widget elementor-widget-image\" data-id=\"6584de1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"658\" height=\"1024\" src=\"https:\/\/www.ufsm.br\/app\/uploads\/sites\/601\/2020\/02\/depende-658x1024.png\" class=\"attachment-large size-large wp-image-6175\" alt=\"\" srcset=\"https:\/\/www.ufsm.br\/app\/uploads\/sites\/601\/2020\/02\/depende-658x1024.png 658w, https:\/\/www.ufsm.br\/app\/uploads\/sites\/601\/2020\/02\/depende-193x300.png 193w, https:\/\/www.ufsm.br\/app\/uploads\/sites\/601\/2020\/02\/depende-768x1195.png 768w, https:\/\/www.ufsm.br\/app\/uploads\/sites\/601\/2020\/02\/depende-988x1536.png 988w, https:\/\/www.ufsm.br\/app\/uploads\/sites\/601\/2020\/02\/depende.png 1030w\" sizes=\"(max-width: 658px) 100vw, 658px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f03e6f7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f03e6f7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c5aed71\" data-id=\"c5aed71\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ef56a94 elementor-widget elementor-widget-text-editor\" data-id=\"ef56a94\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"line-height: 1.38;text-align: justify;margin-top: 0pt;margin-bottom: 0pt\"><span style=\"font-size: 12pt;font-family: Arial;color: #222222;background-color: #ffffff;font-weight: bold;font-style: normal;font-variant: normal;text-decoration: none;vertical-align: baseline\">O que ibuprofeno, diabetes e hipertens\u00e3o t\u00eam em comum?<\/span><\/p><p><b id=\"docs-internal-guid-41b7cd24-7fff-94bb-1a1c-e8343729f262\" style=\"font-weight: normal\">\u00a0<\/b><\/p><p dir=\"ltr\" style=\"line-height: 1.38;text-align: justify;margin-top: 0pt;margin-bottom: 0pt\"><span style=\"font-size: 12pt;font-family: Arial;color: #222222;background-color: #ffffff;font-weight: 400;font-style: normal;font-variant: normal;text-decoration: none;vertical-align: baseline\">O ibuprofeno tem a\u00e7\u00e3o analg\u00e9sica e antiinflamat\u00f3ria. Por isso, \u00e9 indicado para febre, dor de cabe\u00e7a, dor nas costas, dor muscular, dor de dente, artrite e processos inflamat\u00f3rios. Existe uma s\u00e9rie de rem\u00e9dios com ibuprofeno, como Advil, Alivium, Buscofem, Doraliv, Ibuflex, Ibufran, Ibuliv, Lombalgina e Nimesulida.<\/span><\/p><p dir=\"ltr\" style=\"line-height: 1.38;text-align: justify;margin-top: 0pt;margin-bottom: 0pt\"><span style=\"color: #222222;font-family: Arial;font-size: 12pt\">\u00a0<\/span><\/p><p dir=\"ltr\" style=\"line-height: 1.38;text-align: justify;margin-top: 0pt;margin-bottom: 0pt\"><span style=\"color: #222222;font-family: Arial;font-size: 12pt\">Assim como os rem\u00e9dios para diabetes e hipertens\u00e3o, o ibuprofeno\u00a0 aumenta a produ\u00e7\u00e3o de uma enzima, a ECA-2. Essa subst\u00e2ncia age, por exemplo, no relaxamento dos vasos sangu\u00edneos, o que reduz a press\u00e3o arterial.\u00a0\u00a0<\/span><\/p><p dir=\"ltr\" style=\"line-height: 1.38;text-align: justify;margin-top: 0pt;margin-bottom: 0pt\"><span style=\"color: #222222;font-family: Arial;font-size: 12pt\">\u00a0<\/span><\/p><p dir=\"ltr\" style=\"line-height: 1.38;text-align: justify;margin-top: 0pt;margin-bottom: 0pt\"><span style=\"color: #222222;font-family: Arial;font-size: 12pt\">Segundo o estudo da Lancet, o aumento dessa enzima agravaria a infec\u00e7\u00e3o por Covid-19 e aumentariam as chances dos quadros severos do novo coronav\u00edrus.\u00a0<\/span><\/p><p dir=\"ltr\" style=\"line-height: 1.38;text-align: justify;margin-top: 0pt;margin-bottom: 0pt\"><span style=\"color: #222222;font-family: Arial;font-size: 12pt\">\u00a0<\/span><\/p><p dir=\"ltr\" style=\"line-height: 1.38;text-align: justify;margin-top: 0pt;margin-bottom: 0pt\"><span style=\"color: #222222;font-family: Arial;font-size: 12pt\">A pesquisa menciona brevemente o ibuprofeno. O foco do estudo est\u00e1 nas comorbidades e no efeito da enzima.\u00a0<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-caf207b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"caf207b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f7bfffb\" data-id=\"f7bfffb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3de21b7 elementor-widget elementor-widget-text-editor\" data-id=\"3de21b7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h2 style=\"line-height: 1.38;text-align: justify;margin-top: 0pt;margin-bottom: 0pt\"><span style=\"font-size: 12pt;font-family: Arial;color: #222222;background-color: #ffffff;font-weight: bold;font-style: normal;font-variant: normal;text-decoration: none;vertical-align: baseline\">Cientistas precisam de mais evid\u00eancias<\/span><\/h2><div><span style=\"font-size: 12pt;font-family: Arial;color: #222222;background-color: #ffffff;font-weight: bold;font-style: normal;font-variant: normal;text-decoration: none;vertical-align: baseline\">\u00a0<\/span><\/div><p><span style=\"color: #222222;font-family: Arial;font-size: 12pt;text-align: justify;vertical-align: baseline\">\u00c9 importante ressaltar ainda que essa foi uma revis\u00e3o de literatura de pesquisadores su\u00ed\u00e7os e gregos a partir de tr\u00eas estudos anteriores &#8211; um com 1099 pacientes, outro 140 pacientes e outro com 52 pacientes com Covid-19 na China.\u00a0<\/span><span style=\"color: black;font-size: 1rem\">\u00a0<\/span><\/p><p dir=\"ltr\" style=\"line-height: 1.38;text-align: justify;margin-top: 0pt;margin-bottom: 0pt\"><span style=\"font-size: 12pt;font-family: Arial;color: #222222;background-color: #ffffff;font-weight: 400;font-style: normal;font-variant: normal;text-decoration: none;vertical-align: baseline\">As pesquisas sobre os efeitos do ibuprofeno nos infectados com o novo coronav\u00edrus est\u00e3o em fase inicial e carecem de mais evid\u00eancias. Neste sentido, a pr\u00f3pria <\/span><span style=\"font-size: 12pt;font-family: Arial;color: #222222;background-color: transparent;font-weight: 400;font-style: normal;font-variant: normal;text-decoration: none;vertical-align: baseline\">a <a href=\"https:\/\/www.who.int\/\">OMS<\/a> voltou atr\u00e1s e retirou sua recomenda\u00e7\u00e3o de n\u00e3o utilizar o rem\u00e9dio no tratamento da pandemia, por n\u00e3o ter \u201cconhecimento de relatos de efeitos negativos\u201d do medicamento.\u00a0<\/span><\/p><p dir=\"ltr\" style=\"line-height: 1.38;text-align: justify;margin-top: 0pt;margin-bottom: 0pt\"><span style=\"color: #222222;font-family: Arial;font-size: 12pt;background-color: transparent;vertical-align: baseline\">\u00a0<\/span><\/p><p dir=\"ltr\" style=\"line-height: 1.38;text-align: justify;margin-top: 0pt;margin-bottom: 0pt\"><span style=\"color: #222222;font-family: Arial;font-size: 12pt;background-color: transparent;vertical-align: baseline\">Para al\u00e9m das quest\u00f5es apresentadas pelos artigos recentes, a professora Ana Catharina Nastri, do Hospital das Cl\u00ednicas da Faculdade de Medicina da <\/span><a style=\"background-color: #ffffff\" href=\"https:\/\/jornal.usp.br\/atualidades\/ibuprofeno-e-cloroquina-nao-sao-recomendaveis-para-tratar-covid-19\/\"><span style=\"font-size: 12pt;font-family: Arial;color: #1155cc;background-color: transparent;vertical-align: baseline\">USP<\/span><\/a><span style=\"color: #222222;font-family: Arial;font-size: 12pt;background-color: transparent;vertical-align: baseline\">, desaconselha por outra raz\u00e3o. O ibuprofeno pode ocasionar problemas renais e linf\u00e1ticos em pacientes com o novo coronav\u00edrus, segundo a professora.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c5cf750 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c5cf750\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-081d68a\" data-id=\"081d68a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5b31ffb elementor-widget elementor-widget-text-editor\" data-id=\"5b31ffb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: bolder\">Mit\u00f4metro<\/span><em style=\"color: #000000;font-size: 16px\"><span style=\"font-weight: bolder\"> Coronav\u00edrus<\/span>\u00a0\u00e9 um projeto de checagem de fatos da revista Arco voltado para a tem\u00e1tica da pandemia com o objetivo de combater a desinforma\u00e7\u00e3o.<\/em><\/p><p><em style=\"color: #000000;font-size: 16px\"><b>Compreenda os selos<\/b>:<\/em><\/p><p><i><b>Comprovado<\/b> &#8211; fato com evid\u00eancias cient\u00edficas e que pode ser explicado a partir de relat\u00f3rios, documentos e pesquisas confi\u00e1veis e com metodologias fact\u00edveis.\u00a0<\/i><\/p><p><i><b>\u00c9 poss\u00edvel<\/b> &#8211; selo para uma checagem com elementos reais. N\u00e3o h\u00e1 comprova\u00e7\u00e3o 100% em fun\u00e7\u00e3o de determinados ind\u00edcios, detalhes ou situa\u00e7\u00f5es.<\/i><\/p><p><b>Depende &#8211; <\/b><i>\u00e9 o meio termo entre o que \u00e9 mito e a verdade. N\u00e3o existe um consenso entre as fontes e os especialistas. Tamb\u00e9m usado para quando faltam evid\u00eancias ou para destacar que o fato pode ocorrer em uma determinada situa\u00e7\u00e3o.\u00a0<\/i><\/p><p><b>Improv\u00e1vel &#8211; <\/b><i>refere-se a uma situa\u00e7\u00e3o com pouqu\u00edssima possibilidade de ser real.\u00a0<\/i><\/p><p><b>Mito &#8211; <\/b><i>n\u00e3o existe possibilidade alguma de ser verdade. Existem evid\u00eancias que provam o contr\u00e1rio. Enquadram-se aqui as teorias da conspira\u00e7\u00e3o, as lendas da internet e as noticias falsas.<\/i><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8e71906 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8e71906\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8c681f0\" data-id=\"8c681f0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Os efeitos negativos anti inflamat\u00f3rio em rela\u00e7\u00e3o ao Covid-19 n\u00e3o est\u00e3o comprovados, mas pesquisas recentes levantam esse questionamento e formulam algumas hip\u00f3teses. Portanto, faltam evid\u00eancias.<\/p>\n","protected":false},"author":32,"featured_media":6185,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1846],"tags":[4211,4209,4219,2162,4217,540,4235],"class_list":["post-6197","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mitometro","tag-china","tag-coronavirus","tag-covid-19","tag-destaque-ufsm","tag-ibuprofeno","tag-mitometro","tag-pandemia"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ufsm.br\/midias\/arco\/wp-json\/wp\/v2\/posts\/6197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ufsm.br\/midias\/arco\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ufsm.br\/midias\/arco\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ufsm.br\/midias\/arco\/wp-json\/wp\/v2\/users\/32"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ufsm.br\/midias\/arco\/wp-json\/wp\/v2\/comments?post=6197"}],"version-history":[{"count":0,"href":"https:\/\/www.ufsm.br\/midias\/arco\/wp-json\/wp\/v2\/posts\/6197\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ufsm.br\/midias\/arco\/wp-json\/wp\/v2\/media\/6185"}],"wp:attachment":[{"href":"https:\/\/www.ufsm.br\/midias\/arco\/wp-json\/wp\/v2\/media?parent=6197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ufsm.br\/midias\/arco\/wp-json\/wp\/v2\/categories?post=6197"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ufsm.br\/midias\/arco\/wp-json\/wp\/v2\/tags?post=6197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}