Synthesis of 1H-1,2,3-triazoles – Rufinamide analogs by 1,3-dipolar cycloaddition and eletrocyclization reactions of trifluoroacetyl enolethers under thermal solventless conditions.

Journal of Fluorine Chemistry.

Straightforward method for regioselective reduction of 3-acyl-substituted 2-(trifluoromethyl)-2H-chromen-5-one and chromane scaffolds in NaBH4/ethanol medium.

Journal of Fluorine Chemistry.

Evaluation of the synthesis of 1-(pentafluorophenyl)-4,5-dihydro-1H-pyrazoles using green metrics.

Monatshefte Fur Chemie.

Intramolecular cyclization of N-propargylic β-enaminones catalyzed by silver.

Tetrahedron Letters.

A novel, potent, oral active and safe antinociceptive pyrazole targeting kappa opioid receptors.

Neuropharmacology.

New strategy for the regioselective synthesis of 1-phenyl-3-trifluoromethyl-1H-pyrazoles.

Tetrahedron Letters.

2012

Synthesis of novel quinolines using TsOH/ionic liquid under microwave.
Journal of the Brazilian Chemical Society.

Efficient microwave-assisted synthesis of 1-aryl-4-dimethylamino methyleno-pyrrolidine-2,3,5-triones.
Tetrahedron Letters.

Antidepressant-like effect of the novel MAO inhibitor 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mice.
Progress in Neuro-Psychopharmacology & Biological Psychiatry.

Improved One-Pot Synthesis of 1-Aryl-3-trifluoroacetyl-1H-pyrroles under Swern Oxidation.
Synthesis.

New trifluoromethyl-containing (E)-N′-arylidene-[3-alkyl(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-1-yl]carbohydrazides: Synthesis, crystal structure and antimicrobial/antioxidant activity.
Journal of Fluorine Chemistry.

New one-pot, efficient, and regioselective method for the synthesis of 3-Trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs.
Tetrahedron Letters.

Enol ethers and acetals: acylation with dichloroacetyl, acetyl and benzoyl chloride in ionic liquid medium.
Tetrahedron Letters.

Ultrasound promoted the synthesis of N-propargylic β-enaminones.
Ultrasonics Sonochemistry.

Efficient entry to trifluoromethyl substituted chromanes from oxidative aromatization of tetrahydro-2H-chromen-5(6H)-ones using iodine/alcohol with conventional and microwave methods.
Journal of Fluorine Chemistry.

2011

The first application of 4-alkoxy-1,1,1-trifluoroalk-3-en-2-ones in a three-component condensation protocol for the synthesis of 3-acyl-4-aryl-2-(trifluoromethyl)-2-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-ones.

Journal of Fluorine Chemistry, 132(3), 160–165.

An E-factor minimized solvent-free protocol for the preparation of 4,5-dihydro-5-(trifluoromethyl)-1H-pyrazoles.

Monatshefte Für Chemie – Chemical Monthly.

Structural investigations of 5-hydroxy-4,5-dihydroisoxazoles.

Journal of Molecular Structure.

Influence of bulky and halogen substituents on crystal packing of pyrazolo[1,5-a]pyrimidines.

Journal of Molecular Structure.

Efficient and highly regioselective synthesis of ethyl 1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylates under ultrasound irradiation.

Ultrasonics Sonochemistry.

Ionic liquid and Lewis acid combination in the synthesis of novel (E)-1-(benzylideneamino)-3-cyano-6-(trifluoromethyl)-1H-2-pyridones.

Monatshefte Fur Chemie. 

General pathway for a convenient one-pot synthesis of trifluoromethyl-containing 2-amino-7-alkyl(aryl/heteroaryl)-1,8-naphthyridines and fused cycloalkane analogues.

Molecules (Basel, Switzerland)

An efficient and regioselective synthesis of 1,1 ’-oxalylbis 3-(alkyl/aryl/heteroaryl)-5-(trihalomethyl)-1H-pyrazoles from 4-alkoxy-1,1,1-trihaloalk-3-en-2-ones.

Monatshefte Fur Chemie.

2010 – 2006

Synthesis and in Vitro Antimycobacterial Activity of 3-Substituted 5-Hydroxy-5-Trifluoro[chloro]methyl-4,5-Dihydro-1H-1-(isonicotinoyl) Pyrazoles.

International Journal of Antimicrobial Agents.

Regiospecific Synthesis of Trichloromethyl Substituted 4,5-Dihydro-1H-1- Tosylpyrazoles.

Journal of Heterocyclic Chemistry.

The Efficient One-Step Synthesis of Protected 6-Alkyl(aryl)-2-Acetylamino-4(3H)-Pyrimidinones

Letters in Organic Chemistry.

The Unexpected Cyclization Routes of N , N 0 -Bis ( Oxotrifluoroalkenyl ) – 1 , 3-Phenylenediamines in Polyphosphoric Acid Medium.

Tetrahedron Letters.

Succinic Acid Dihydrazide: A Convenient N,N-Double Block for the Synthesis of Symmetrical and Non-Symmetrical Succinyl-Bis 5-Trifluoro(chloro)methyl-1H-Pyrazoles.

Journal of the Brazilian Chemical Society.

Synthesis of New Trifluoromethyl-Containing Cycloalka B Quinolines Derived from Alkoxycycloalkenes.

Arkivoc

General Method for Dehydration, Intramolecular Cyclization, and Fluorination of trifluoromethy1-1H-Pyrazoles Using DAST.

Tetrahedron Letters

New Efficient Approach for the Synthesis of 2-Alkyl(aryl) Substituted 4 H -pyrido[1,2- a]pyrimidin-4-Ones.

Journal of Heterocyclic Chemistry.

Preparation of Novel Trifluoroacetylketene O,N-Acetals and Trifluoromethyl-Containing S,S-Sulfoximido N-Substituted Heterocycles.

Journal of the Brazilian Chemical Society.

Convergent Procedure for the Synthesis of Trifluoromethyl-Containing N-(pyridinyl-Triazolyl)pyrimidin-2-Amines.

Journal of Fluorine Chemistry.

Alkoxyvinyl Trifluoromethyl Ketones as Efficient Precursors for the One-Pot Synthesis of Bis-(4,5-Dihydro-1H-Pyrazol-1-Yl)methanones and 1H-Pyrazolyl-1-Carbohydrazides.

Arkivoc.

One-Pot Synthesis of N 2 -Aminoprotected 6-Substituted and Cycloalka[D] 4-Trifluoromethyl-2-Acetylaminopyrimidines.

Journal of Heterocyclic Chemistry.

The First Synthesis of Dihydro-3H-pyrido[2,3-b][1,4]diazepinols and a New Alternative Approach for Diazepinone Analogues.

Tetrahedron Letters.

Regiospecific Synthesis of 3 H -pyrido[2,3- B ][1,4]diazepin-4(5 H )-Ones via Haloform Reaction with the Isolation of N 3 -[3-Oxo-4,4,4-Trichloroalk-1-En-1-Yl]-2,3-Diaminopyridine Intermediates.

Journal of Heterocyclic Chemistry.

Preparation of New 2-Amino- and 2,3-Diamino-Pyridine Trifluoroacetyl Enamine Derivatives and Their Application to the Synthesis of Trifluoromethyl-Containing 3H-pyrido[2,3-b][1,4] Diazepinols.

Journal of Heterocyclic Chemistry.

Synthesis of New Trihalomethylated and Non-Symmetrical Substituted 2-(1H-Pyrazolyl)-5-(1H-Pyrazolylcarbonyl)pyridines.

Journal of the Brazilian Chemical Society.

DAST Promotes the Synthesis of New 5-(trifluoromethyl)-3-(1,1-Difluoroethan-2-Yl)-1H-Pyrazoles.

Tetrahedron Letters.

Trifluoromethyl-Containing Pyrazolinyl (p-Tolyl) Sulfones: The Synthesis and Structure of Promising Antimicrobial Agents.

Journal of Fluorine Chemistry.

2-Trifluoroacetyl-1-Methoxycycloalkenes: A Convenient Precursor for the Synthesis of Geminated Polymethylene Trifluoromethyl Substituted Heterocycles.

Journal of Heterocyclic Chemistry.

Preparation of Trichloroacetoamidoxime in Aqueous Media and Application in One Pot Synthesis of 1,2,4-Oxadiazoles.

Arkivoc.

The Structure in the Solid State and in Solution of 3(5)-Trifluoromethyl-4,5(3)-Polymethylenepyrazoles.

Arkivoc.

Antimalarial Activity of 4-(5-Trifluoromethyl-1H-Pyrazol-1-Yl)-Chloroquine Analogues.

Bioorganic & Medicinal Chemistry Letters.

A N Efficient and Green Synthesis of 1 , 4-Dihydropyridine Derivatives through Multi-Component Reaction in Ionic Liquid.

Heteroatom Chemistry.

The Regiospecific ??-Bromination of 2-Trichloroacetylcycloalkanones.

Tetrahedron Letters.

Flores, Alex F C, Alex F C Flores, Lucas Pizzuti, Lucas Pizzuti, Sergio Brondani, Sergio Brondani, and others, ‘Alex F. C. Flores,* Lucas Pizzuti, Sergio Brondani, Marcelo Rossato, Nilo Zanatta and Marcos A. P. Martins’, Synthesis, 18 (2007), 1316–21

Efficient Synthesis of New 1-[Alkyl(aryl)]-5-(3,3,3-Trihalo-2-Oxopropylidene)pyrrolidin-2-Ones.

Journal of the Brazilian Chemical Society.

Regiospecific Synthesis of 5-Trichloromethyl-1H-Pyrazole and 1HPyrazole-5-Carboxylic Ester Derivatives.

Letters in Organic Chemistry.

Synthesis of New 2-(5-Aryl-3-Styryl-4,5-Dihydro-1 H -Pyrazol-1-Yl)-4-(trifluoromethyl)pyrimidines.

Synthesis.

Supramolecular Structure of Enaminones in Solid-State.

Journal of Molecular Structure.

2-Methyl-5-(4-Tolyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine.

Acta Crystallographica Section E Structure Reports Online.

Ionic Liquid Effects on the Reaction of β-Enaminones and Tert-Butylhydrazine and Applications for the Synthesis of Pyrazoles.

Catalysis Communications.

Ionic Liquid as Catalyst in the Synthesis of N-Alkyl Trifluoromethyl Pyrazoles.

Catalysis Communications.

Molecular Structure of pyrazolo[1,5-A]pyrimidines: X-Ray Diffractometry and Theoretical Study.

Journal of Molecular Structure.

An Efficient Solvent-Free Synthesis of NH-Pyrazoles from ??-Dimethylaminovinylketones and Hydrazine on Grinding.

Tetrahedron Letters.

2-(4,5-Dihydro-1,3-Oxazol-2-Yl)quinoline.

Acta Crystallographica Section E Structure Reports Online.

Experimental and Calculated Structural Parameters of 5-Trihalomethyl-4,5-Dihydro-1H-Pyrazole Derivatives, Novel Analgesic Agents.

Journal of Molecular Structure.

Synthesis and Structure of Novel 4,5-Dihydro-1H-Pyrazoles: Salicylic Acid Based Analgesic Agents.

Arkivoc.

Antioxidant Potential of New Pyrazoline Derivatives to Prevent Oxidative Damage.

Basic & Clinical Pharmacology & Toxicology.

Microwave-Assisted Synthesis of Novel 5-Trichloromethyl-4,5-Dihydro-1H-1-Pyrazole Methyl Esters under Solvent Free Conditions.

Journal of the Brazilian Chemical Society.

Highly Regioselective Synthesis of Novel 1,4 ’-Bipyrazoles.

Journal of the Brazilian Chemical Society.

Synthesis of ??-Enaminones by Ionic Liquid Catalysis: A One-Pot Condensation under Solvent-Free Conditions.

Catalysis Communications.

An Ionic Liquid as Reaction Medium for the Synthesis of Halo-Containing ??-Enaminones at Room Temperature.

Monatshefte Fur Chemie.

Ionic Liquids Promoted the C-Acylation of Acetals in Solvent-Free Conditions.

Catalysis Letters.

Synthesis of 1,1,1-Trichloro[fluoro]-3-Alken-2-Ones Using Ionic Liquids.

Journal of Molecular Catalysis A: Chemical.

Reaction of ??-Alkoxyvinyl Halomethyl Ketones with Cyanoacetohydrazide.

Journal of the Brazilian Chemical Society.

Ultrasound Promoted Synthesis of 5-Hydroxy-5-Trihalomethyl-4,5-Dihydroisoxazoles and ??-Enamino Trihalomethyl Ketones in Water.

Ultrasonics Sonochemistry.

Preparation of Novel 5-Alkoxy-1,1,1,2,2-Pentafluoroalk-4-En-3-Ones and Their Application to a One-Pot Synthesis of Azoles.

Arkivoc.

Microwave Assisted Regiospecific Synthesis of 5-Trifluoromethyl-4,5-Dihydropyrazoles and Pyrazoles.

Journal of Heterocyclic Chemistry.

2-Methyl-7-Substituted pyrazolo[1,5-A]pyrimidines: Highly Regioselective Synthesis and Bromination.

Journal of the Brazilian Chemical Society.

Synthesis of Novel Conjugated Enynes: A Reaction of Lithium Acetylenides with β-Dimethylaminovinyl Ketones.

Arkivoc.

Microwave-Assisted Synthesis and Antimicrobial Activity of 5-Trihalomethyl-3-Arylisoxazoles.

Monatshefte Für Chemie – Chemical Monthly.

A Solvent-Free Synthesis of Beta-Enamino Trihalomethyl Ketones.

Journal of the Brazilian Chemical Society.

Solvent-Free Route to Î2-Enamino Dichloromethyl Ketones and Application in the Synthesis of Novel 5-Dichloromethyl-1 H -Pyrazoles.

Journal of Heterocyclic Chemistry.

X-Ray Structure, Semi-Empirical MO Calculations and π-Electron Delocalization of 1-Cyanoacetyl-5-Trifluoromethyl-5-Hydroxy-4,5-Dihydro-1H-Pyrazoles.

Journal of Molecular Structure.

Synthesis of Novel 3-Amino-5-Trifluoromethylazoles: A Convenient Method of Obtaining N -(Azol-3-Yl)amines.

Synthesis.

5-Halomethyl-5-Hydroxy-4,5-Dihydroisoxazoles: Synthesis and 13C, 17O,15N, 19F NMR Spectroscopy.

Mini-Reviews in Organic Chemistry.

Antinociceptive Effect of Novel Trihalomethyl-Substituted Pyrazoline Methyl Esters in Formalin and Hot-Plate Tests in Mice.

European Journal of Pharmacology.

Antinociceptive Action of 4-Methyl-5-Trifluoromethyl-5-Hydroxy-4, 5-Dihydro-1H-Pyrazole Methyl Ester in Models of Inflammatory Pain in Mice.

Life Sciences.

An Efficient Synthesis of 1-Cyanoacetyl-5-Halomethyl-4,5-Dihydro-1H-Pyrazoles in Ionic Liquid.

Monatshefte Für Chemie – Chemical Monthly.

Ionic Liquid Promoted Cyclocondensation Reactions to the Formation of Isoxazoles, Pyrazoles and Pyrimidines.

Catalysis Communications.

Antinociceptive Effect of a Novel Tosylpyrazole Compound in Mice.

Basic and Clinical Pharmacology and Toxicology.

Synthesis of New Halo-Containing Enynes: Reaction of Lithium Acetylenides with 1,1,1-Trihalo-4-Alkoxy-3-Buten-2-Ones.

Letters in Organic Chemistry.

Antipyretic and Antioxidant Activities of 5-Trifluoromethyl-4,5-Dihydro-1H-Pyrazoles in Rats.

Brazilian Journal of Medical and Biological Research.

Indium-Mediated Allylation of α, α-Dichloroketones: The Synthesis of 1,1-Dichloro-2-Organyl-Pent-4-En-2-Ols.

Letters in Organic Chemistry.

A Pyrazolyl-Thiazole Derivative Causes Antinociception in Mice.

Brazilian Journal of Medical and Biological Research.

A Convenient Method for the Synthesis of 1,5-Benzodiazepin-2-One.

The Open Organic Chemistry Journal.

Reaction of ??-Dimethylaminovinyl Ketones with Hydroxylamine: A Simple and Useful Method for Synthesis of 3- and 5-Substituted Isoxazoles.

Journal of Heterocyclic Chemistry.

N- and C-Acylation in β-Enamino Ketones: Structural Effects on Regiocontrol’.

Synlett.

Straightforward and Regiospecific Synthesis of Pyrazole-5-Carboxylates from Unsymmetrical Enaminodiketones.

Synlett.

Microwave-Assisted Regiospecific Synthesis of 2-Trifluoromethyl-7- Trihalomethylated Pyrazolo[1,5-a]Pyrimidines.

Letters in Organic Chemistry.

Synthesis of Ethyl Pyrimidine-4-Carboxylates from Unsymmetrical Enamino Diketones and Their Application in the First Synthesis of Pyrimido[4,5-D]pyridazin-8(7 H)-Ones.

Synthesis.

Ultrasound Promoted Synthesis of 2-Imidazolines in Water: A Greener Approach toward Monoamine Oxidase Inhibitors.

Bioorganic and Medicinal Chemistry Letters.

Effect of 5-Trifluoromethyl-4,5-Dihydro-1H-Pyrazoles on Chronic Inflammatory Pain Model in Rats.

European Journal of Pharmacology.

Design and Microwave-Assisted Synthesis of 5-Trifluoromethyl-4,5-Dihydro-1H-Pyrazoles: Novel Agents with Analgesic and Anti-Inflammatory Properties.

European Journal of Medicinal Chemistry.

Synthesis, Antimicrobial Activity, and QSAR Studies of Furan-3-Carboxamides.

Bioorg Med Chem.

Synthesis and Characterization of Some Novel 2-(Trifluoromethyl)pyrimido[1,2- a ]benzimidazoles and Pyrimido[1,2- a ]benzimidazol-2 H )-Ones of Biological Interest.

Synthesis.

Convergent Synthesis and Cruzain Inhibitory Activity of Novel 2-(N′-Benzylidenehydrazino)-4-Trifluoromethyl-Pyrimidines.

Bioorganic and Medicinal Chemistry.

Synthesis and Antimicrobial Activity of New (4,4,4-Trihalo-3-Oxo-but-1-Enyl)-Carbamic Acid Ethyl Esters, (4,4,4-Trihalo-3-Hydroxy-Butyl)-Carbamic Acid Ethyl Esters, and 2-Oxo-6-Trihalomethyl-[1,3]oxazinane-3-Carboxylic Acid Ethyl Esters.

Bioorganic & Medicinal Chemistry.

Synthesis and Characterization of New Trifluoromethyl Substituted 3-Ethoxycarbonyl- and 3-Pyrimidin-2-Yl)-(1,2,3)-Oxathiazinane-S-Oxides.

Journal of Heterocyclic Chemistry.

Synthesis, Screening for Antiacetylcholinesterase Activity and Binding Mode Prediction of a New Series of [3-(disubstituted-Phosphate)-4,4,4-Trifluoro-Butyl]-Carbamic Acid Ethyl Esters.

Journal of the Brazilian Chemical Society.

Regiospecific Bromination of 2-Phenyl-3H-Pyrimidin-4-Ones.

Synthesis.

A Convenient Synthesis of 5- and 6-Substituted 2-Phenyl-3 H -Pyrimidin-4-Ones.

Synthesis.

Comparative Study of the Chemoselectivity and Yields of the Synthesis of N-Alkyl-4-(trihalomethyl)-1H-Pyrimidin-2-Ones.

European Journal of Organic Chemistry.

Highly Chemoselective Synthesis of 6-Alkoxy-1-Alkyl(aryl)-3-Trifluoroacetyl-1,4,5,6-Tetrahydropyridines and 1-Alkyl(aryl)-6-Amino-3-Trifluoroacetyl-1,4,5,6-Tetrahydropyridines.

European Journal of Organic Chemistry.

An Efficient Synthesis of Oxa- and Aza-Condensed Tetrahydropyridines from Cyclic Enones.

Synthesis-Stuttgart.

A Convenient Two-Step Synthesis of 6-Methylenesubstituted-4-Trichloromethyl-2-Methylsulfanyl Pyrimidines.

Tetrahedron Letters.

Synthesis and Structural Study of a New Series of 2-Methylsulfanyl-Tetrahydropyrimidines from Beta-Alkoxyvinyl Trihalomethyl Ketones.

Regiospecific Synthesis of 4-Alkoxy and 4-Amino Substituted 2-Trifluoromethyl Pyrroles.

J. Org. Chem.

A Simple One-Pot Synthesis of 3-Alkoxy-3-Cyanocarboxylic Acids: A Rapid Entry to New GABA Derivatives.

Tetrahedron Letters.

Convenient One-Pot Synthesis of N-Substituted 3-Trifluoroacetyl Pyrroles.

Synlett.

A Novel Camphorsulfonyloxylactonization of Alkenoic Acids.

Journal of Heterocyclic Chemistry.

2005 – 2001

An Efficient and Regiospecific Preparation of Trifluoromethyl Substituted 4-(1H-Pyrazol-1-Yl)-7-Chloroquinolines.

Journal of Heterocyclic Chemistry

Regiospecific One-Pot Synthesis of New Trifluoromethyl Substituted Heteroaryl Pyrazolyl Ketones.

Journal of Heterocyclic Chemistry.

Synthesis of Some N- 1-alkyl(aryl)3-Oxo-4,4,4-Trichloro(trifluoro)-1-Buten-1-Yl -O-Aminoph Enols and O-Phenylenediamines as Potential Anticancer Agents.

Synthetic Communications.

Cyclocondensation Reaction of 4-Aryl-4-Methoxy-1,1,1-Trifluoro-3-Buten-2-Ones with Urea.

Journal of Fluorine Chemistry.

Solvent Effects on the 17O NMR Chemical Shifts of 4-Dimethylsulfoximide-1,1,1-Trifluoro-3-Alken-2-Ones.

Journal of Fluorine Chemistry.

Pyrimidinones, and Their Thioxo Analogs from 2‐Trifluoroacetyl‐1‐methoxycycloalkenes.

Synthetic Communications.

Synthesis, 17O NMR Spectroscopy and Structure of 2-Trifluoroacetyl-1-Methoxycycloalkenes.

Journal of Fluorine Chemistry.

Synthesis of New Fluorine-Containing Dihydrobenzo[c]acridines from Trifluoroacetyl Dihydronaphthalene and Substituted Anilines.

Journal of Fluorine Chemistry.

Preparation and Crystal Structure Determination of Adducts of copper(II) Chloride with 3-Aryl-1-(imino-Pyridin-2-Yl-Methyl)-5-Hydroxy-5-Trifluoromethyl-4,5-Dihydro-1H-Pyrazoles.

Inorganic Chemistry Communications.

Reactions of β-Methoxyvinyl Trifluoromethyl Ketones with 2-Pyridinecarboxamidrazone A Convenient Route to Trifluoromethylated 4,5-Dihydro-1H-1-Picolinoylpyrazole Hydrochlorides.

Journal of Fluorine Chemistry.

β-Alkoxyvinyl Trichloromethyl Ketones as N-Heterocyclic Acylating Agent. A New Access to 5H-thiazolo[3,2-A]pyrimidin-5-Ones.

Tetrahedron Letters.

Efficient Synthesis and Dehydration Reaction of Trichloromethylated 2-(3-Phenyl-5-Hydroxy-4,5-Dihydro-1H-Pyrazol-1-Yl)-4-Aryl-5-Alkylthiazoles.

Heteroatom Chemistry.

Regiospecific Synthesis of New Non-Condensed Heteropolycyclic Systems from β-Heteroaryl-β-Methoxyvinyl Trihalomethyl Ketones.

Journal of the Brazilian Chemical Society.

Regiospecific Synthesis of 3-Alkyl-2-Aryl-4-Trifluoromethylbenzo[h]quinolines by Intramolecular Cyclization of N-(2-Alkyl-1-Aryl-3-Oxo-4,4,4-Trifluorobut-1-En-1-Yl)-1-Naphthylamines.

Synthesis.

Regiospecific Cyclization of β-Methoxyvinyl Trifluoromethyl Ketones with Aminoguanidine: A Convenient Method to Obtain Trifluoromethylated 2-[1H-Pyrazol-1-Yl]pyrimidines,

Synthesis.

Inhibitory Effect of Novel Pyrimidines on ATP and ADP Hydrolysis in Synaptosomes from Rat Cerebral Cortex.

Chemical Research in Toxicology.

Haloacetylated Enol Ethers: 16 5 Regiospecific Synthesis of 5-Trichloromethyl-Pyrazoles.

Synthetic Communications.

Synthesis of Hydroxypyrazoles and 1-Methyl-3-Isoxazolones via Haloform Reactions.

Tetrahedron Letters.

Synthesis of 1,1,1-Trihalo-4-Methoxy-4-[2-Heteroaryl]-3-Buten-2-Ones, the Corresponding Butan-1,3-Dione and Azole Derivatives.

Tetrahedron Letters.

Reactions of β-alkoxyvinyl trifluoromethyl ketones. The synthesis of n -[1-aryl-3-oxo-4,4,4-trifluoro-1-buten-1-yl]- o -phenylenediamines and 4-aryl-2-trifluoromethyl- 3h -1,5-benzodiazepines.

Synthetic Communications.

α2-Adrenoceptors and 5-HT Receptors Mediate the Antinociceptive Effect of New Pyrazolines, but Not of Dipyrone.

European Journal of Pharmacology.

{17}O NMR Chemical Shifts: Torsion Angle Relationships In 3-Alkyl Substituted 4,5-Dihydroisoxazoles and Isoxazoles.

Spectrosc. Lett.

Regiospecific Synthesis of 1,2-Bis(azolyl)ethanes.

Journal of the Brazilian Chemical Society.

Synthesis of New Halo-Containing Acetylenes and Their Application to the Synthesis of Azoles.

Tetrahedron Letters.

Molecular structure of heterocycles. V. Solvent effects on the 17 o nmr chemical shifts of 5-trichloromethyl-5-hydroxy-4, 5-dihydroisoxazoles.

Spectroscopy Letters.

Molecular Structure of Heterocycles: 6. Solvent Effects on the 17O Nmr Chemical Shifts of 5-Trichloromethylisoxazoles.

Journal of the Brazilian Chemical Society.

15N NMR Spectroscopy of 3-Substituted 5-Trichloromethyl-1,2-Dimethyl-1H-Pyrazolium Chlorides.

Magnetic Resonance in Chemistry.

Regiospecific Synthesis of Polyfluorinated Heterocycles.

Journal of Fluorine Chemistry.

Indium(III) Bromide Catalyzed One-Pot Synthesis of Trichloromethylated Tetrahydropyrimidinones.

Tetrahedron Letters.

4-Alkoxy-1,1,1-Trichloro-3-Alken-2-Ones: Preparation and Applications in Heterocyclic Synthesis.

Current Organic Synthesis.

One‐Pot Synthesis of Pyrazole‐5(3)‐carboxyamides.

Synthetic Communications.

A Convenient Synthesis of 5-Trichloromethyl-5-Hydroxy-3-Heteroalkyl-4,5-Dihydroisoxazoles.

Synthesis.

Microwave Assisted Synthesis of 5-Hydroxy-5-Trichloromethyl-4,5-Dihydroisoxazoles.

Tetrahedron Letters.

5-Trifluoromethyl-1,2-Dimethyl-1H-Pyrazolium Chlorides: Synthesis and NMR Chemical Shifts.

Journal of Fluorine Chemistry.

Microwave-Assisted Synthesis of 5-Trichloromethyl Substituted 1-Phenyl-1H-Pyrazoles and 1,2-Dimethylpyrazolium Chlorides.

Tetrahedron Letters.

Haloacetylated Enol Ethers: 18’

Journal of Fluorine Chemistry.

Haloacetylated enol ethers. Xvii.1* a convenient synthesis of 5-trichloromethyl-1,2-dimethyl- 1h-pyrazolium chlorides.

Synthetic Communications.

Chelating Effect of Novel Pyrimidines in a Model of Aluminum Intoxication.

Journal of Inorganic Biochemistry.

Effects per Se of Organic Solvents in the Cerebral Acetylcholinesterase of Rats.

Neurochemical Research.

Effects of Potassium Alkali and Calcium Supplementation on Bone Turnover in Postmenopausal Women.

Journal of Clinical Endocrinology and Metabolism.

Hypothermic and Antipyretic Effects of 3-Methyl- and 3-Phenyl-5-Hydroxy-5-Trichloromethyl-4,5-Dihydro-1H-Pyrazole-1-Carboxyamides in Mice.

European Journal of Pharmacology.

Antinociceptive Effect of Novel Pyrazolines in Mice.

Brazilian Journal of Medical and Biological Research.

Baker Yeast-Induced Fever in Young Rats: Characterization and Validation of an Animal Model for Antipyretics Screening.

Journal of Neuroscience Methods.

Non-Condensed Trifluoromethylated 5, 5-Bicycles : Synthesis of.

New York, 2002, 17–20

Regiospecific Cyclization of 4-Alkoxyvinyl Trifluoro Chloro Methyl Ketones with 6-Trifluoro Chloro Methyl-2-Hydrazine Pyrimidines. A Convenient Method to Obtain Trifluoro Chloro Methylated 2-(5-Hydroxy-5-Trifluoro Chlorolmethyl-4,5-Dihydro-1H-Pyrazol-1-Yl.

Synthesis-Stuttgart.

Synthesis of Novel Trifluoromethylated Beta-Acetal-Diols and Their Application to the Synthesis of 3-Ethoxy-5-Hydroxy-5-Trifluoromethyl-Pyrrolidin-2-One.

Journal of Fluorine Chemistry.

Convenient Synthesis of Furan-3-Carboxylic Acid and Derivatives.

Tetrahedron Letters.

Synthesis of 4-(trihalomethyl)dipyrimidin-2-Ylamines from β-Alkoxy-α,β-Unsaturated Trihalomethyl Ketones.

Journal of Heterocyclic Chemistry.

A convenient synthesis of 4-trichloromethyl-pyrimidin-2-ylamine derivatives.

Synthetic Communications.

One-Pot Synthesis of a New Series of 3-Alkoxy-5-Hydroxy-5-Trifluoromethylpyrrolidin-2-Ones from 1,1,1-Trifluoro-4-Alkoxyalk-3-En-2-Ones.

Synthesis.

Synthesis of N-Substituted 6-Trifluoromethyl-1,3-Oxazinanes.

Journal of the Brazilian Chemical Society.

Application of 4-Alkoxy-1,1,1-Trifluoro[chloro]alk-3-En-2-Ones as Selective Protecting Groups of Amino Acids.

Synthesis.

2000…

A Convenient Synthetic Method for Fully Conjugated 3-Alkyl- and 3-Aryl-5-Trifluoromethyl-1-Methyl-1,2-Thiazine 1-Oxide from β-Alkoxyvinyl Trifluoromethyl Ketones.

 Synthesis.

1999

Trifluoroacetylation of Unsymmetrical Ketone Acetals. A Convenient Route to Obtain Alkyl Side Chain Trifluoromethylated Heterocycles.

Journal of Fluorine Chemistry.

O-17 NMR Chemical Shifts: A Simple and Useful Rule for Substituent Additivity on Oxygen Atoms with a Coordination Number of Two.

Magnetic Resonance in Chemistry.

Regiospecific Acylation of Acetals. A Convenient Method to Obtain ??- Methoxyvinyl Trichloromethyl Ketones.

Tetrahedron Letters.

A Convenient One-Pot Synthesis of 5-Carboxyisoxazoles: Trichloromethyl Group as a Carboxyl Group Precursor.

Tetrahedron Letters.

Regiochemistry of the Reaction of 2-Acylcyclohexanones with Trimethyl Orthoformate: A Convenient One-Pot Method to Obtain 7,7-Dimethoxy Alkanoate Methyl Esters.

Synlett.

Reactions of 1,1,1-Trifluoro[chloro]-4-Ethoxybut-3-En-2-Ones with 1,3-Dicarbonyl Compounds: Synthesis of 5-Acetyl[carboxyethyl]-1,1,1-Trifluoro[chloro]hept-3-Ene-2,6-Diones and Their Cyclic Derivatives Phenol, Pyridines, and Azetone.

Synthesis. 

1998

Haloacetylated Enol Ethers 10. Condensation of β-Alkoxyvinyl Trifluoromethyl Ketones with Thiosemicarbazide. Synthesis of New Trifluoromethyl 4,5-Dihydro-1H-1-Pyrazolethiocarboxyamides.

Journal of Fluorine Chemistry.

1996

Haloacetylated Enol Ethers. 6 [5]. Synthesis of 4,5-Trimethylene-4,5-Dihydroisoxazoles.

 Journal of Heterocyclic Chemistry.

1992

Determinação da Energia de Ativação na Temperatura de Coalescência: Avaliação do Método para a N-Etil- N-Metilacetamida.

Química Nova.

1991

Trihaloacetylated Enol Ethers – General Synthetic Procedure and Heterocyclic Ring Closure Reactions with Hydroxylamine

Synthesis (Stuttg). 

1988

13C/1H Long Range Coupling in Configuration Assignment of Tri-Substituted Alkeres.

 Química Nova

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Reviews

Abaixo estão relacionados os Reviews publicados pelo grupo NUQUIMHE.

2020

Brominated β-Alkoxyvinyl Trihalomethyl Ketones as Promising Synthons in Heterocyclic Synthesis

Synthesis

2014

Update 1 of: Ionic Liquids in Heterocyclic Synthesis

Chemical Reviews.

2009

Solvent-Free Heterocyclic Synthesis

Chemical Reviews.

2008

Ionic Liquids in Heterocyclic Synthesis.

Chemical Reviews.

5-Halomethyl-5-Hydroxy-4,5-Dihydroisoxazoles: Synthesis and 13C, 17O, 15N, 19F NMR Spectroscopy

Mini-Reviews in Organic Chemistry.

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